Commensal bacteria as signal mediators within a mammalian host

Details Commensal bacteria as signal mediators within a mammalian host Commensal bacteria as signal mediators within a mammalian host

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) A61K 35/74 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 14/605 (2006.01) C07K 14/62 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2758023

Genetically engineered cells and microorganisms are provided for preventing or ameliorating diseases through genetically engineered quorum signaling. Therapeutic methods for using the cells and microorganisms to prevent or ameliorate diseases are also provided. The genetically engineered cells or microorganisms can be engineered to express a signal and used to interrupt the signaling-dependent virulence of an invading pathogen. The cells or microorganisms can be used to provide signal-dependent expression of a desirable gene in order to interrupt, prevent, and/or ameliorate a disease of mammals, such as parasitic diseases, infectious diseases, autoimmune diseases and genetic disorders.

L'invention concerne des cellules et des micro-organismes modifiés génétiquement pour empêcher ou améliorer des maladies par l'intermédiaire d'une signalisation de quorum génétiquement modifié. Des procédés thérapeutiques pour utiliser les cellules et les micro-organismes pour empêcher ou améliorer des maladies sont également décrits. Les cellules ou micro-organismes génétiquement modifiés peuvent être modifiés pour exprimer un signal et utilisés pour interrompre la virulence, en fonction de la signalisation, d'un pathogène envahissant. Les cellules ou micro-organismes peuvent être utilisés pour fournir une expression en fonction d'un signal d'un gène souhaitable afin d'interrompre, dempêcher et/ou daméliorer une maladie de mammifères, telle que des maladies parasitaires, des maladies infectieuses, des maladies auto-immunes et des troubles génétiques.

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