C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12Q 1/04 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2468888
A novel protein Common Lymphatic Endothelial and Vascular Endothelial Receptor- 1 (CLEVER-1) is described. CLEVER-1 mediates leukocyte and malignant cell binding to vascular and lymphoid endothelial cells. CLEVER-1 is the first protein that has been reported to mediate both influx into and efflux from the lymph nodes. Also provided are methods of treating inflammation and preventing metastasis of malignant cells by providing an inhibitor of CLEVER-1 binding.
Cette invention concerne une nouvelle protéine, dite récepteur-1 endothélial lymphatique et endothélial vasculaire commun (CLEVER-1). Cette protéine CLEVER-1 agit sur la liaison des leucocytes et des cellules malignes avec des cellules endothéliales vasculaires et lymphoïdes. CLEVER-1 est la première molécule dont on a signalé qu'elle agissait à la fois sur l'entrée et la sortie des noeuds lymphatiques. Son également décrites des méthodes permettant de traiter une inflammation et de prévenir les métastases de cellules malignes à l'aide d'un inhibiteur de liaison de CLEVER-1.
Irjala Heikki
Jalkanen Sirpa
Salmi Marko
Faron Pharmaceuticals Oy
Irjala Heikki
Jalkanen Sirpa
Robic
Salmi Marko
LandOfFree
Common lymphatic endothelial and vascular endothelial... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Common lymphatic endothelial and vascular endothelial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Common lymphatic endothelial and vascular endothelial... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1736164