Compact member comprising a plurality of porous cellulose...

Details Compact member comprising a plurality of porous cellulose... Compact member comprising a plurality of porous cellulose...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2271652

The invention relates to a compact member comprising a plurality of porous cellulose matrices (PCMs), and providing extended release of an active compound located in the pores of said PCMs together with a release-modifying agent. The friability of the compact member is less than 2.1%, and the disintegration time in vitro of said compact member is less than 240 minutes. The compact member is manufactured by exposing a plurality of PCMs to an active compound and a release-modifying agent, in optional sequence or mixture, for a time sufficient for said active compound and release-modifying agent to fill the pores in said PCMs to a preselected level. The PCMs are subsequently compacted to a desired shape. The invention further relates to use of the compact members for administration of a drug.

L'invention concerne un élément compact composé d'une pluralité de matrices poreuses en cellulose (PCM) et permettant de libérer de façon prolongée un composé actif situé dans les pores desdites matrices avec un agent modifiant la libération. Le caractère friable de cet élément compact est inférieur à 2,1 % et le temps de désintégration in vitro dudit élément compact est inférieur à 240 minutes. On fabrique cet élément compact par exposition d'une pluralité de matrices poreuses (PCM) à un composé actif et à un agent modifiant la libération, dans une séquence ou dans un mélange éventuels, pendant une durée suffisante au remplissage des pores dans lesdites matrices jusqu'à un niveau présélectionné, par ledit composé actif et par ledit agent modifiant la libération. On rend ensuite ces matrices compactes jusqu'à obtention de la forme souhaitée. L'invention concerne, de plus, l'utilisation d'éléments compacts pour l'administration d'un médicament.

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