Companion diagnostic assays for cancer therapy

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G06F 19/28 (2011.01) C40B 30/04 (2006.01)

Patent

CA 2671399

Methods for identifying cancer patients eligible to receive Bcl-2 family inhibitor therapy and for monitoring patient response to Bcl-2 family inhibitor therapy comprise assessment of the expression levels of the biomarker combinations set out in TABLES 1, 2, 3, 4, 5 or 6 in a patient tissue sample. The methods of the invention allow more effective identification of patients to receive Bcl-2 family inhibitor therapy and of determination of patient response to the therapy.

La présente invention concerne des procédés destinés à identifier des patients atteints d'un cancer éligibles pour recevoir un traitement à base d'inhibiteurs de la famille Bcl-2 et à surveiller la réaction des patients à un traitement à base d'inhibiteurs de la famille Bcl-2, qui comprennent l'évaluation des niveaux d'expression des combinaisons de marqueurs biologiques indiqués dans les TABLEAUX 1, 2, 3, 4, 5 ou 6 dans un échantillon de tissu des patients. Les procédés de l'invention permettent une identification plus efficace des patients aptes à recevoir un traitement à base d'inhibiteurs de la famille Bcl-2 et une détermination plus efficace de la réaction des patients au traitement.

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