C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2369878
The present invention provides methods of determining relative copy number of target nucleic acid sequences and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acid sequences immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acid sequences are hybridized. The hybridization of the labeled nucleic acid sequences to the solid surface is then detected using standard techniques.
Cette invention se rapporte à des procédés servant à déterminer le nombre de copies relatives de séquences d'acide nucléique cibles et le mappage précis des anomalies chromosomiques liées à une maladie. Ces procédés utilisent des séquences d'acide nucléique cibles immobilisées sur une surface solide, à laquelle est lié par hybridation un échantillon comprenant deux groupes de séquences d'acide nucléique différemment marquées. L'hybridation des séquences d'acide nucléique marquées à la surface solide est ensuite détectée à l'aide de techniques classiques.
Albertson Donna G.
Baldocchi Russell A.
Collins Colin C.
Gray Joe W.
Pinkel Dan
Fetherstonhaugh & Co.
The Regents Of The University Of California
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