C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12M 3/00 (2006.01)
Patent
CA 2634447
Disclosed herein pertains to a method of evaluating genomic DNA comprising the steps of: a) providing a genomic DNA sample; b) providing a particle mixture, the mixture comprises particles from different particle sets, wherein each particle set contains numerous encoded particles and a nucleic acid hybridisation probe for particular genomic locus, such that the mixture col-lectively includes probes for a plurality of different genomic loci; c) contacting the sample to a portion of the particle mixture under hybridisation conditions; and d) evaluating hybridisation of the sample to particles in respective portion of the mixture by monitoring a detectable label, wherein signals from the monitoring are indicative of the number of copies of each interrogated genomic locus. The invention further pertains to a particle mixture comprising particles from different particles sets thereof.
L'invention concerne des procédés et des compositions pour évaluer un contenu génomique à l'aide de particules codées afin d'évaluer de multiples échantillons en parallèle.
Adler Karl Edwin Jr.
Bobrow Mark N.
Schermer Mack J.
Perkinelmer Las Inc.
Smart & Biggar
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