C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/04 (2006.01) C07H 21/00 (2006.01) C07K 14/345 (2006.01) C07K 14/35 (2006.01) C12N 15/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2438279
The present invention is directed to a method of selection of purified nucleotidic sequences or polynucleotides encoding proteins or part of proteins carrying at least an essential function for the survival or the virulence of mycobacterium species by a comparative genomic analysis of the sequence of the genome of M. tuberculosis aligned on the genome sequence of M. leprae and M. tuberculosis and M. leprae marker polypeptides of nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed.
L'invention porte sur un procédé de sélection de séquences nucléotidiques purifiées ou de polynucléotides codant pour des proteines ou des parties de proteines porteuses d'au moins une fonction essentielle influant sur la survie ou la virulence d'espèces du type mycobacterium, par analyse génomique comparative de la séquence du génome du M. tuberculosis alignée sur la séquence du génome due M. leprae, sur les polypeptides marqueurs du M. tuberculosis et du M. leprae des nucléotides codant pour lesdits polypeptides, et sur des procédés d'utilisation desdits nucléotides et polypeptides codés.
Institut Pasteur
Robic
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