B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 19/00 (2006.01) C07K 1/04 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2582470
The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluid.ic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co~- compartmentalised into the microcapsules.
La présente invention concerne un procédé de synthèse de composés comprenant les étapes consistant: (a) à répartir au moins deux ensembles de composés primaires dans des microcapsules de façon qu'une certaine proportion de ces microcapsules contienne au moins deux composés; et (b) à former des composés secondaires dans les microcapsules au moyen de réactions chimiques réalisées entre des composés primaires de différents ensembles, l'étape (a) et/ou (b) étant mise(s) en oeuvre sous contrôle microfluidique, de préférence sous contrôle microfluidique électronique. Cette invention permet également d'identifier des composés qui se lient à un composant cible d'un système biochimique ou qui modulent l'activité de la cible et qui sont co-répartis dans des microcapsules.
Ahn Keunho
Bibette Jerome
Griffiths Andrew
Link Darren
Weitz David
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Medical Research Council
President And Fellows Of Harvard College
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