C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 35/74 (2006.01) A61K 39/00 (2006.01) C07K 14/32 (2006.01) C12N 9/10 (2006.01) C12N 15/31 (2006.01) C12N 15/54 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01)
Patent
CA 2359210
The invention relates to host cells that contain at least two functional recombinant polypeptides, at least one of which is bound to a substrate, preferably each one in different cell compartments, for example, the cytosol, the cytoplasmic membrane, the periplasm and the outer membrane. The invention also relates to a method for producing said host cells. The inventive cells are especially useful as bioreactors for carrying out enzymatic reaction cascades for which a compartmentalization of individual enzymes is advantageous or required.
L'invention concerne des cellules hôtes qui contiennent au moins deux polypeptides recombinants fonctionnels dont au moins un se présente sous forme liée à un porteur, de préférence chacun dans des compartiments cellulaires distincts, par exemple le cytosol, la membrane cytoplasmique, le périplasme et la membrane externe. L'invention concerne également leur procédé de production. Les cellules selon l'invention conviennent tout particulièrement comme bioréacteurs pour l'exécution de cascades de réactions enzymatiques dans lesquelles un compartimentage des différentes enzymes est avantageux ou nécessaire.
Lubitz Werner
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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