Competitive inhibitors of invariant chain expression and/or...

Details Competitive inhibitors of invariant chain expression and/or... Competitive inhibitors of invariant chain expression and/or...

C - Chemistry, Metallurgy

07

K

C07K 7/04 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2703585

The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting- the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmutne disease, cancer, Alzheimer's disease, allergic disease, transplant and cell graft rejection, HIV infection and other viral, bacterial, and parasitic infection, and AIDS. Methods are also provided for preparing a peptide having the property of being able to displace CLIP by feeding one or more peptide sequences into software that predicts MHC Class II binding regions in an antigen sequence and related products.

L'invention concerne des procédés pour moduler la fonction immune par le ciblage de molécules CLIP. Le résultat est une large gamme de nouveaux schémas thérapeutiques pour traiter, inhiber l'évolution de, ou autrement traiter une multitude de maladies et de troubles, y compris des maladies auto-immunes, le cancer, la maladie d'Alzheimer, les allergies, le rejet d'un transplant ou d'une greffe de cellules, une infection à VIH et autres infections virales, bactériennes et parasitaires, et le SIDA. L'invention comprend également des procédés pour préparer un peptide qui possède la propriété de pouvoir déplacer un CLIP en alimentant une ou plusieurs séquences de peptides dans un logiciel qui prédit les régions de liaison d'un CMH de classe II dans une séquence antigène et les produits connexes.

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