C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 3/02 (2006.01) C07K 14/47 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2549477
Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mRNA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the IL-6 pathway, whereas soluble hemojuvelin (s- hemojuvelin) suppressed hepcidin mRNA expression in primary human hepatocytes in a log- linear dosedependent manner. Disclosed are compositions and methods for modulating diseases of iron metabolism and hepcidin expression or hepcidin levels.
Ganz Tomas
Goldberg Yigal P.
Lin Lan
Gowling Lafleur Henderson Llp
The Regents Of The University Of California
Xenon Pharmaceuticals Inc.
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