Complement antagonists and uses thereof

Details Complement antagonists and uses thereof Complement antagonists and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 31/712 (2006.01) A61K 31/7125 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2730203

Disclosed are antagonists designed to inhibit or block expression of a mammalian complement such as complement component 6 (C6). The invention has a wide range of uses including use in the preparation of a medicament for the enhancement of nerve regeneration following acute or chronic nerve damage in a mammal. Additional applications include use in the treatment of multiple sclerosis either alone or in combination with another drug.

La présente invention concerne des antagonistes destinés à inhiber ou bloquer lexpression dun complément de mammifère, par exemple le composant 6 du complément (C6). Linvention a une vaste gamme dutilisations, y compris lutilisation dans la préparation dun médicament destiné à améliorer la régénération nerveuse après une lésion nerveuse aiguë ou chronique chez un mammifère. Dautres applications comprennent lutilisation dans le traitement de la sclérose en plaques seul ou en combinaison avec un autre médicament.

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