C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01)
Patent
CA 2616135
Peptides corresponding partially to positions 55-64 of the sequence of the complement component peptide C3a are capable of preventing and treating mast cell- and basophil-mediated disorders by inhibiting IgE- or IgG-mediated triggering and/or by inhibiting the Fc.epsilon.RI- and/or Fc.gamma.R-induced secretory response, while obviating the anaphylatoxic response. These peptides are useful for prevention and/or treatment of allergic disorders where mucosal- type and/or serosal-type mast cells and/or basophils are involved such as asthma, allergic dermatosis, and gastrointestinal allergies.
L'invention concerne des peptides correspondant partiellement aux positions 55-64 de la séquence du peptide constituant du complément C3a, lesquels permettent d'empêcher et de traiter des troubles à médiation par des mastocytes ou par des basophiles, par inhibition du déclenchement à médiation par IgE ou IgG et/ou par inhibition de la réponse de sécrétion induite par Fc.epsilon.RI et/ou Fc.gamma.R, tout en évitant la réponse anaphylatoxique. Ces peptides sont utiles dans la prévention et/ou le traitement de troubles allergiques dans lesquels des mastocytes et/ou basophiles de type muqueux et/ou séreux sont impliqués, tels que l'asthme, la dermatose allergique et les allergies gastro-intestinales.
Erdei Anna
Pecht Israel
Ridout & Maybee Llp
Yeda Research & Development Co. Ltd.
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