C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) A01K 67/027 (2006.01) C12N 15/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2734304
Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fhBp) are provided, as well as non-human animal models of Neisserial infection.
L'invention porte sur des dosages destinés à la détection d'anticorps anti-Neisseria bactéricides à l'aide d'un polypeptide de facteur H comportant une séquence d'acides aminés humaine qui est un médiateur de la liaison à la protéine de liaison au facteur H de Neisseria (fhBp), ainsi que sur des modèles animaux non humains d'une infection par Neisseria.
Granoff Dan M.
Ram Sanjay
Welsch Jo Anne
Children's Hospital & Research Center At Oakland
Novartis Vaccines And Diagnostics Srl
Smart & Biggar
The University Of Massachusetts
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