A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 16/36 (2006.01) C12N 5/12 (2006.01)
Patent
CA 2457461
The invention relats to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the activity of C5b. One example of such an inhibitors molecule is the monoclonal antibody designated MAb137-26 which binds to a shared epitope of human C5 and C5a. These inhibitors may be used to inhibit the activity of C5a in treating diseases and conditions mediated bx excessive or uncontrolled production of C5a. The inhibitors moleculesl are also useful for diagnostic detection of the presence/absence or amount of C5 or C5a.
La présente invention concerne des inhibiteurs qui se fixent à C5 et à C5a mais qui n'empêchent ni l'activation de C5 ni la formation ou l'activité de C5b. Un exemple d'une telle molécule inhibitrice est l'anticorps monoclonal appelé MAb137-26, lequel se fixe à un épitope commun aux composants C5 et C5a humains. Ces inhibiteurs peuvent être utilisés pour inhiber l'activité de C5a pendant le traitement de maladies et d'affections provoquées par une production excessive ou non-régulée de C5a. Ces molécules inhibitrices sont également utilisées pour la détection à but diagnostique de la présence/absence ou de la quantité de C5 ou C5a.
Fung Michael S. C.
Lu Meisheng
Sun Cecily
Sun William
Genentech Inc.
Sim & Mcburney
Tanox Inc.
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