Complementary adenoviral vector systems and cell lines

Details Complementary adenoviral vector systems and cell lines Complementary adenoviral vector systems and cell lines

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/861 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2238295

The present invention provides multiply replication deficient adenoviral vectors having a spacer in at least one replication deficient adenoviral region, as well as complementing cell lines therefor. Also provided are means of constricting the multiply replication deficient adenoviral vectors and methods of use thereof, e.g., in gene therapy.

Vecteurs adénoviraux à déficience de réplication multiple, comportant un espaceur dans au moins une région adénovirale à réplication déficiente et lignées cellulaires complémentaires. L'invention porte également sur un dispositif de construction de vecteurs adénoviraux à déficience de réplication multiple et sur leurs méthodes d'utilisation, en thérapie génétique par exemple.

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