Complete mitochondrial genome sequences as a diagnostic tool...

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G06F 17/30 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2450004

The examination of mutations in the mitochondrial genome is used as a diagnostic system for diseases such as pxostate cancer, and non melanoma skin cancer. Characteristic mutations and rearrangements including, paint mutations (transitions, transversions), deletions, inversions, duplications, recombinations, insertions or combinations thereof in the mitochondrial genome are used as early indicators of prostate cancer, and non melanoma skin cancer. Moreover, the 4977 bp, or "common deletion" as well as other associated mutations and/or deletions are used as a measure of aging.

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