Complete mitochondrial genome sequences as a diagnostic tool...

Details Complete mitochondrial genome sequences as a diagnostic tool... Complete mitochondrial genome sequences as a diagnostic tool...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2550135

The examination of mutations in the mitochondrial genome is used as a diagnostic system for diseases such as prostate cancer, and non melanoma skin cancer. Characteristic mutations and rearrangements including, point mutations (transitions, transversions), deletions, inversions, duplications, recombinations, insertions or combinations thereof in the mitochondrial genome are used as early indicators of prostate cancer, and non melanoma skin cancer. Moreover, the 4977 bp, or "common deletion" as well as other associated mutations and/or deletions are used as a measure of aging.

L'examen de mutations dans le génome mitochondrial est utilisé comme un système de diagnostic pour des maladies, telles que le cancer de la prostate et le cancer de la peau non-mélanome. Des mutations et des réarrangements caractéristiques, notamment des mutations ponctuelles (transitions, transversions), des effacements, des inversions, des duplications, des recombinaisons, des insertions ou des combinaisons de ceux-ci dans le génome mitochondrial, sont utilisés comme indicateurs précoces du cancer de la prostate et du cancer de la peau non-mélanome. De plus, le bp 4977 ou "l'effacement commun", ainsi que d'autres mutations et/ou effacements associés sont utilisés comme mesure du vieillissement.

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