Complex cationic lipids

Details Complex cationic lipids Complex cationic lipids

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/16 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07C 225/06 (2006.01) C07C 229/12 (2006.01) C07C 237/06 (2006.01) C07C 271/12 (2006.01) C07C 271/20 (2006.01) C07C 275/14 (2006.01) C07C 279/12 (2006.01) C07C 279/36 (2006.01) C07C 323/59 (2006.01) C07C 333/04 (2006.01) C07C 335/08 (2006.01) C07C 391/00 (2006.01) C07H 21/00 (2006.01) C07K 5/083 (2006.01) C07K 5/097 (2006.01)

Patent

CA 2237316

Cationic lipids, having a derivated quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for negatively charged macromolecules. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.

L'invention porte sur des lipides cationiques présentant un groupe de tête constitué par un ammonium quaternaire dérivatisé qui en améliore la capacité de ciblage des cellules et en augmente l'efficacité de transfection des macromolécules chargées négativement. Ces lipides comportent un liant dont les groupes fonctionnels offrent des sites permettant la fixation ultérieure de médicaments, de ligands de cellules réceptrices ou d'autres agents bioactifs.

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