C - Chemistry – Metallurgy – 40 – B
Patent
C - Chemistry, Metallurgy
40
B
C40B 20/04 (2006.01) C07B 61/00 (2006.01) C07C 205/59 (2006.01) C07C 245/14 (2006.01) C07C 331/28 (2006.01) C07D 243/24 (2006.01) C07H 21/00 (2006.01) C07K 1/04 (2006.01) C07K 2/00 (2006.01) C12Q 1/68 (2006.01) C40B 50/16 (2006.01) G01N 31/22 (2006.01) G01N 33/532 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2143848
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of com-pounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two dif-ferent groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or high-er code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reac-tion history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.
Dillard Lawrence W.
Ohlmeyer Michael H. J.
Reader John C.
Still W. Clark
Wigler Michael H.
Cold Spring Harbor Laboratory
Gowling Lafleur Henderson Llp
The Trustees Of Columbia University
The Trustees Of Columbia University In The City Of New York
LandOfFree
Complex combinatorial chemical libraries encoded with tags does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Complex combinatorial chemical libraries encoded with tags, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Complex combinatorial chemical libraries encoded with tags will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1730217