A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/5415 (2006.01)
Patent
CA 2583783
.The invention concerns a complex comprising mequitazine, a cyclodextrin and an interactive agent characterized in that the solubilizing rate in water of the complexed mequitazine, measured for a mixture at 2g/l of mequitazine in water at 35 °C after being stirred for 15 minutes, in higher than 50 % at a pH of 9. The invention also concerns a method for preparing said complex and a pharmaceutical composition comprising same.
La présente invention concerne un complexe comprenant la méquitazine, une cyclodextrine et un agent d'interaction caractérisé en ce que le taux de solubilisation dans l'eau de la méquitazine complexée, mesuré pour un mélange à 2g/l de méquitazine dans l'eau à 35~C après 15 minutes d'agitation, est supérieur à 50% à pH 9. Elle concerne également un procédé de préparation de ce complexe et une composition pharmaceutique le comprenant.
Freiss Bernard
Lochard Hubert
Pierre Fabre Medicament
Robic
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