Complex for in-vivo target localization

Details Complex for in-vivo target localization Complex for in-vivo target localization

C - Chemistry, Metallurgy

07

K

C07K 17/02 (2006.01) A61K 9/16 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61K 51/12 (2006.01) C07B 59/00 (2006.01) C07C 43/11 (2006.01) C07C 217/42 (2006.01) C08B 37/02 (2006.01) A61K 49/02 (1990.01)

Patent

CA 2082943

2082943 9118020 PCTABS00008 To localize targets within the body, antibodies are linked via polysaccharide or polymer spacer arms to rapidly cleared, Tc-99m labeled submicron-sized, albumin microspheres. The polysaccharide or polymer spacer arms are attached to the surface of the microspheres to provide hydrophilic, sterically free binding sites with a high loading capacity for targeting or effector molecules. These labelled albumin targeting microspheres may be used to detect a variety of sites of clinical interest using non-invasive external imaging devices and may be employed to carry therapeutic agents to these sites.

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