Complex formation between dsdna and oligomer of heterocycles

Details Complex formation between dsdna and oligomer of heterocycles Complex formation between dsdna and oligomer of heterocycles

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 47/48 (2006.01) C07D 207/34 (2006.01) C07D 233/90 (2006.01) C07D 403/14 (2006.01) C07K 7/02 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2288806

Methods and compositions are provided for forming complexes between dsDNA and oligomers of heterocycles, aliphatic amino acids, particularly omega-amino acids, and a polar end group. By appropriate choice of target sequences and composition of the oligomers, complexes are obtained with low dissociation constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or expression of undesired genes.

L'invention concerne des procédés et des compositions permettant de former des complexes entre un ADN à double brin et des oligomères d'hétérocycles, des acides aminés aliphatiques, plus particulièrement des acides oméga-aminés et un groupe terminal polaire. En sélectionnant de manière adéquate les séquences cibles et la composition d'oligomères, on obtient des complexes avec des constantes de faible de dissociation. La formation de complexes peut être utilisée pour identifier des séquences spécifiques d'ADN à double brin, pour inhiber la transcription de gènes et, comme agent thérapeutique, pour inhiber la prolifération de cellules indésirables ou l'expression de gènes indésirables.

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