A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/30 (2006.01) A61K 9/26 (2006.01) A61K 45/06 (2006.01) A61K 47/12 (2006.01) A61K 47/22 (2006.01) A61K 47/34 (2006.01) A61K 47/36 (2006.01) A61K 31/366 (2006.01) A61K 31/405 (2006.01)
Patent
CA 2592287
A complex formulation for oral administration comprising a sustained release formulation of an HMG-CoA reductase inhibitor and a film layer for rapid release of an anti-hypertensive agent, the film layer being coated on the sustained release formulation, can achieve improved therapeutic effects of the anti-hypertensive agent by promptly releasing it, while maintaining a constant drug level of the HMG-CoA reductase inhibitor in blood through a slow release. Accordingly, the complex formulation is useful for preventing and treating diseases such as hyperlipidemia, atherosclerosis, hypertension and cardiovascular disease.
L'invention concerne une formulation de complexe destinée à une administration orale comprenant une formulation à libération soutenue d'un inhibiteur de réductase HMG-CoA et d'une couche de film à libération rapide d'un agent anti-hypertensif, la couche de film étant revêtue sur la formulation à libération soutenue, ce qui permet d'améliorer les effets thérapeutiques de l'agent anti-hypertensif par libération rapide de celui, tout en maintenant un niveau de médicament constant de l'inhibiteur de réductase HMG-CoA dans le sang à travers une libération lente. Selon cette invention, la formulation de complexe est utile dans la prévention et le traitement de maladies telles que l'hyperlipidémie, l'athérosclérose, l'hypertension et les maladies cardiovasculaires.
Chi Moon Hyuk
Kim Yong Il
Woo Jong Soo
Cassan Maclean
Hanmi Pharm. Co. Ltd.
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