Complex mixtures exhibiting selective inhibition of...

A - Human Necessities – 61 – K

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A61K 31/122 (2006.01) A23L 1/30 (2006.01) A61K 31/00 (2006.01) A61K 31/12 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2450478

A novel formulation is provided that serves to specifically inhibit the COX-2 mediated inflammatory response in animals. The formulation comprises comprising an effective amount of component I selected from the group consisting of alpha acids and beta acids and an effective amount of at least one component II selected from the group consisting of alpha acids, beta acids, essential oils, fats and waxes, with the proviso that component I and II are not the same compound. The composition provides specific inhibition of cyclooxygenase-2 with little or no effect on cyclooxygenase-1.

L'invention concerne une nouvelle préparation capable, en particulier, d'inhiber la réponse inflammatoire induite par la COX-2 chez des animaux. La préparation comprend une quantité efficace d'un composant I choisi dans le groupe constitué d'acides alpha et d'acides bêta, et une quantité efficace d'au moins un composant II choisi dans le groupe constitué d'acides alpha, d'acides bêta, d'huiles essentielles, de graisses et de cires, pour autant que les composants I et II soient différents. La composition permet une inhibition spécifique de la cyclo-oxygénase-2 sans affecter, ou peu, la cyclo-oxygénase-1.

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