Complex pantoic acid ester neopentyl sulfonyl ester...

C - Chemistry – Metallurgy – 07 – C

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C07C 309/15 (2006.01) A61K 31/255 (2006.01) A61K 31/661 (2006.01) A61P 25/00 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2703831

Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate of formula (I), pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neu-rodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, sub-stance abuse disorders, binge eating disorders, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis and pain are disclosed.

La présente invention concerne des promédicaments ester de néopentyle sulfonyle d'ester d'acide pantoïque d'acamprosate de formule (I), des compositions pharmaceutiques comprenant les promédicaments, et des procédés d'utilisation de ces promédicaments ainsi que leurs compositions pour traiter des maladies. En particulier, l'invention concerne des promédicaments à base d'acamprosate présentant une meilleure biodisponibilité orale et des procédés d'utilisation de promédicaments à base d'acamprosate pour traiter des troubles neurodégénératifs, des troubles psychotiques, des troubles de l'humeur, des troubles de l'anxiété, des troubles somatiques, des troubles du mouvement, des troubles dûs à l'abus de substances, de l'hyperphagie boulimique, des troubles liés à une dépression d'étalement cortical, du tintement, des troubles du sommeil, de la sclérose en plaques et de la douleur.

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