C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
195/140, 195/78,
C08B 37/00 (2006.01) C07H 11/00 (2006.01) C08B 37/10 (2006.01)
Patent
CA 1277937
" Complexable heterogeneous oligosaccharides and alpha-hydosanes having therapeu- tical activity, process for their preparation and related pharmaceutical compositions" ABSTRACT Complexable heterogeneous oligosaccharides and pure fractions of heparan sulphate, namely not contaminated from other macromolecules (mucopolysaccharides, proteins, nucleic acids, etc.) of a defined molecular weight are produced starting from a mixture of mucopolysaccharides obtained starting from bovine or swine mucosa through a process comprising a precipitation with organic solvents, a further purification by means of specific enzymes and chromatographic separation by gel filtration. Heterogeneous oligosaccharides are obtained which can be complexed with metals, being thus able to promote the pharmacological effect of the metal thanks to thegreater permeability towards the complexes of the membrane of the cells of the absorbing mucosa and of the cells of the target tissue. There are also obtained pure fractions of heparan sulphate having a well defined molecular weight range capable of providing several pharmacological activities, more particularly an activating effect of the anti-thrombine III, a potentiating effect of the tissutal activator and a fibrine depolymerizing effect have been found for some of them, whereas for some others an effect on the factor Xa/PTT ratio has been revealed and lastly for still others a lipasemic and anti-coagulating activity has been found.
458868
Baldacci Massimo
Baldacci Ugo
Laboratori Baldacci S.p.a.
Marks & Clerk
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