Complexes containing perfluoroalkyl with polar radicals,...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/14 (2006.01) A61K 49/04 (2006.01) A61K 49/10 (2006.01) C07D 257/02 (2006.01) C07D 295/26 (2006.01)

Patent

CA 2419259

The invention relates to complexes containing perfluoroalkyl with polar radicals of general formula (I), wherein R represents the polar radical, Rf is a perfluorated carbon chain, K is a metal complex and Z is a linker group. The inventive complexes are suitable for intravenous lymphography, tumor diagnosis and infarct and necrosis imaging.

L'invention concerne des complexes perfluoroalkylés à résidus polaires, de formule générale (I), dans laquelle R désigne le résidu polaire, R¿f? désigne une chaîne carbonée perfluorée, K désigne un complexe métallique, et Z désigne un groupe de liaison. Ces complexes conviennent pour l'utilisation en lymphographie intraveineuse, dans le diagnostic des tumeurs et en imagerie d'infarctus et de nécroses.

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