C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/505 (2006.01)
Patent
CA 2509140
The invention relates to complexes of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6- methyl~pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide having the following formula I: The invention also relates to pharmaceutical compositions containing the complexes of formula I. The invention further relates to methods of treating hyperproliferative diseases, such as cancers, in mammals, especially humans by administering the above complexes and to methods of preparing the above complexes.
L'invention concerne des complexes de <i>E-2</i>-méthoxy-N-(3-{4-[3-méthyl-4-(6-méthyl-pyridin-3-yloxy)-phénylamino]-quinazolin-6-yl}-allyl)-acétamide correspondant à la formule I. Elle concerne aussi des compositions pharmaceutiques contenant les complexes correspondant à la formule I. Elle concerne également des procédés pour traiter des maladies hyperprolifératives telles que le cancer chez les mammifères et notamment chez les humains par l'administration desdits complexes, et des procédés de préparation de ces complexes.
Kath John Charles
Leonard Jason Albert
Li Zheng Jane
Morris Joel
Richter Daniel Tyler
Pfizer Products Inc.
Sim & Mcburney
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