Complexes of flavanolignanes with phospholipids, preparation...

Details Complexes of flavanolignanes with phospholipids, preparation... Complexes of flavanolignanes with phospholipids, preparation...

C - Chemistry, Metallurgy

07

F

167/244, 260/354

C07F 9/10 (2006.01) A61K 31/685 (2006.01) C07D 407/04 (2006.01)

Patent

CA 1259324

- 20 - Abstract: COMPLEXES OF FLAVANOLIGNANES WITH PHOSPHOLIPIDS, PREPARA- TION THEREOF AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS The invention relates to novel compounds comprising lipophilic complexes of silybin, silidianin, and silicri- stin with phospholipids, and the preparation of these complexes by non-conventional methods. Absorption of the novel compounds in the gastrointestinal tract is apprecia- bly greater, resulting in higher plasma levels than for the individual flavanolignanes. The resulting improvement in the pharmacokinetic and pharmacological parameters is such that the substances can advantageously be used in the treatment of acute and chronic liver disease of toxic, metabolic or infective origin or of degenerative nature.

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