C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 5/09 (2010.01) A61K 35/12 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C12N 15/09 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01)
Patent
CA 2691785
The present invention relates to agents that modulate interle.upsilon.kin-15 ("IL-15") signal transduction or function ("Therapeutic Agents") and the use ol" those agents to modulate immune function. The Therapeutic Agents target the interaction between IL-15 and its receptor and modulate IL-15-induced signal transduction. The Therapeutic Agents may be formulated with polymers, such as poly-.beta.- 1- ~4-N-acetylglucosamine. for administration to a human subject to modulate IL-15-mediated immune function.
La présente invention concerne des agents (= agents thérapeutiques =) qui modulent la transduction du signal ou la fonction de l'interle?kine-15 (= Il-15 =) et l'utilisation de ces agents pour moduler la fonction immune. Les agents thérapeutiques ciblent l'interaction entre Il-15 et son récepteur et modulent la transduction du signal induit par Il-15. Les agents thérapeutiques peuvent être formulés avec des polymères, tels que la poly-ß-1,4-N-acétylglucosamine en vue d'une administration à un être humain permettant de moduler la fonction immune médiée par Il-15.
Felber Barbara K.
Finkielsztein Sergio
Pavlakis George N.
Vournakis John N.
Departmen T. Of Health And Human Services The United States Of America As Represented By The Secretary
Marine Polymer Technologies Inc.
Osler Hoskin & Harcourt Llp
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