Complexes of nitric oxide with cardiovascular amines as dual...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/815 (2006.01) A61K 31/195 (2006.01) A61K 38/04 (2006.01) A61K 38/31 (2006.01) A61K 38/58 (2006.01) C07C 279/14 (2006.01) C07C 291/04 (2006.01) C07K 7/00 (2006.01) C07K 14/655 (2006.01) C08B 37/00 (2006.01) C08B 37/10 (2006.01)

Patent

CA 2184753

Novel complexes of nitric oxide (NO) and amines are described where the amine is a known cardiovascular agent having at least one or more primary or secondary amino groups and whereby the resulting complex is capable under physiological conditions of releasing in vivo dual active ingredients, the NO and the known cardiovascular agent. The complexes are used for treating cardiovascular diseases and for the prophylactic or therapeutic treatment of restenosis.

Nouveaux complexes formés par l'oxyde nitrique (NO) et des amines, dans lesquels l'amine est un agent cardio-vasculaire connu comprenant au moins un groupe aminé principal ou secondaire, le complexe obtenu étant susceptible, dans des conditions physiologiques, de libérer in vivo des principes à double activité, le NO et l'agent cardio-vasculaire connu. Ces complexes sont utilisés pour traiter des maladies cardio-vasculaires ainsi que pour le traitement ou la prophylaxie de la resténose.

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