Complexes of technetium-99m with alkylene amine oximes

Details Complexes of technetium-99m with alkylene amine oximes Complexes of technetium-99m with alkylene amine oximes

C - Chemistry, Metallurgy

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167/48, 260/428.

C07F 13/00 (2006.01) A61K 51/04 (2006.01) C07C 51/363 (2006.01) C07C 53/19 (2006.01) C07C 207/00 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01)

Patent

CA 1231715

A B S T R A C T Complexes of Technetium-99m with Alkylene Amine Oximes Complexes of technetium-99m with alkylene amine oximes having 2 or 3 carbon atoms in the alkylene group have a core with a zero net charge, contain an O-H-O ring closure bond and are sufficiently stable for parenteral administra-tion. Such complexes are believed to include the structure Image where n is 2 or 3. The complexes can be made by reacting in aqueous solution under reducing conditions pertechnetate with an ethylene or propylene amine oxime. Lipophilic or other groups can be provided on any of the carbon atoms shown to give technetium-99m complexes useful for body imaging. Preferred complexes are capable of diffusing across the blood brain barrier and can be used for brain scanning.

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