Complexing agents and targeting radioactive immunoreagents...

C - Chemistry – Metallurgy – 12 – N

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C12N 9/00 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07D 213/53 (2006.01) C07D 213/55 (2006.01) C07D 213/61 (2006.01) C07D 213/77 (2006.01) C07D 471/04 (2006.01) C07D 471/18 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C12N 1/00 (2006.01) C12N 5/00 (2006.01) C12N 7/01 (2006.01) A61K 43/00 (1990.01) A61K 49/02 (1990.01)

Patent

CA 2095123

2095123 9208494 PCTABS00013 A targeting radioactive immunoreagent comprises a metal radionuclide ion, a complexing agent, and an immunoreactive group covalently bonded to said complexing agent, the complexing agent having structure (A-I), wherein R represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R1 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R2 represents hydroxy, carboxy, hydroxyalkyl, carbonyliminodiacetic acid, methyleneiminodiacetic acid, methylenethioethyleneiminodiacetic acid, hydrazinylylidenediacetic acid, or a salt of such acids, or two R2 groups, taken together, represent the atoms necessary to complete a macrocyclic ring structure containing at least one heteroatom coordinating site and at least one, preferably two alkylene groups forming part of the ring structure; R3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; R4 represents hydrogen or a protein reactive group; n is 0 to 4, o is 0 or 1, m is 0 or 1; provided that at least one of n and m is 0 and at least one of R, R1, R3 and R4 is a protein reactive group. In a composition of matter aspect, this invention provides novel terpyridines and phenanthrolines. Preferred terpyridines have the structure (A-I) above wherein n=1, m=0 and R is a substituted phenyl containing an alkyl or alkoxy substituent and a protein reactive group. Preferred phenanthrolines have the structure (A-I) above wherein n=0, m=1 and at least one R4 is a protein reactive group. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Complexing agents and targeting radioactive immunoreagents... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Complexing agents and targeting radioactive immunoreagents..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Complexing agents and targeting radioactive immunoreagents... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1401091

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.