Complexing urushiols

Details Complexing urushiols Complexing urushiols

A - Human Necessities

61

K

A61K 31/72 (1995.01)

Patent

CA 2214083

This invention relates to use of cyclodextrins to complex urushiols to protect against and to treat irritation arising from exposure to urushiols. Cyclodextrins, particularly gamma-cyclodextrins, are capable of binding strongly to urushiols and can be used effectively to prevent irritation of tissue that is exposed to urushiols. Cyclodextrin-urushiol complexes can also be used to desensitize against urushiol. Compositions containing cyclodextrin/urushiol complexes may be provided as tablets for buccal administration in dosages sufficient to induce desensitizing response.

Cette invention concerne l'utilisation de cyclodextrines pour complexer des urushiols, afin de protéger contre l'irritation provoquée par les urushiols et la traiter. Les cyclodextrines et en particulier les cyclodextrines gamma sont capables de se lier fortement aux urushiols et peuvent être utilisées efficacement pour empêcher l'irritation de tissus exposés à des urushiols. Les complexes cyclodextrine-urushiol peuvent également être utilsés pour provoquer une désensibilisation vis-à-vis des urushiols. L'invention concerne également des compositions contenant des complexes cyclodextrine-urushiol se présentant sous la forme de comprimés administrés par voie orale, en doses suffisantes pour provoquer une réaction de désensibilisation.

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