Components of the presenilin-complex

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 45/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2490278

The present invention is based on a novel direct interaction between a Presenilin and a novel protein identified herein and named Sambiasin-1, a homolog thereof named Sambiasin-2, as well as a protein complex further comprising a Nicastrin. Also comprised are uses of said components and complexes, as well as methods for use of the protein and the complex, inter alia, screening, diagnosis and therapy, as well as methods of preparing the complexes.

La présente invention a trait à une nouvelle interaction directe entre une préséniline et une nouvelle protéine identifiée et désignée la Sambiasine-1, un homologue de celle-ci désignée la Sambiasine-2, ainsi qu'un complexe de protéine comportant en outre la nicastrine. L'invention a également trait aux utilisations desdits constituants et des complexes, ainsi que des procédés d'utilisation de la protéine et du complexe, entre autres, pour le criblage, le diagnostic et la thérapie, et des procédés pour la préparation des complexes.

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