Composite extracellular matrix materials and medical...

Details Composite extracellular matrix materials and medical... Composite extracellular matrix materials and medical...

A - Human Necessities

61

L

A61L 31/12 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2734560

Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non- expanded collagenous materials Methods for their preparation and use are also disclosed. Cer-tain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under con-ditions effective to expand the first collagenous material, and recovering the expanded material Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume

Certains aspects de l'invention concernent des produits de matériaux de matrices extracellulaires composites comprenant des matières collagènes expansées combinées ou non à des matières collagènes non expansées. L'invention concerne également leurs procédés de préparation et d'utilisation. Certaines matières collagènes expansées peuvent être préparées par traitement d'une première matière collagène avec une substance alcaline dans des conditions efficaces pour expanser la première matière collagène, et par récupération de la matière expansée. Les matières expansées peuvent présenter des caractéristiques de persistance et de génération de tissus bénéfiques lorsqu'elles sont implantées, et peuvent être utilisées dans la formation de corps d'implants médicaux hautement poreux qui peuvent être compressés en fractions de leur volume original et qui récupèrent ensuite sensiblement leur volume original.

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