A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/48 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/19 (2006.01) A61K 31/455 (2006.01) A61K 31/485 (2006.01)
Patent
CA 2218486
Mechanically activated composites including pharmaceutically active substances and sodium starch glycolate as a support material are prepared by high energy co-grinding the parmaceutically active substances and sodium starch glycolate to obtain the mechanically activated composites having substantially increased rates of dissolution, enhanced solubilization kinetics, greater bioavailability, and improved peak drug levels in plasma of the pharmaceutically active substances when compared with the active substances per se or known formulations thereof.
L'invention concerne différents composés activés mécaniquement, comprenant des substances pharmaceutiquement actives et du glycolate d'amidon de sodium servant de matériau support, que l'on prépare en procédant à un broyage à haute énergie des substances pharmaceutiquement actives et du glycolate susmentionné. Les composés activés mécaniquement qui résultent de l'opération présentent une amélioration sensible des vitesses de dissolution, de la cynétique de solubilisation, de la biodisponibilité et des niveaux de pointe du médicament dans le plasma de substances pharmaceutiquement actives par rapport aux substances actives proprement dites ou à leur formulation connue.
Carli Fabio
Shah Jatin J.
Shinal Edward C.
Mccarthy Tetrault Llp
Vectorpharma - Eon N.a.
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