Composition and bag for preservation of blood platelets

Details Composition and bag for preservation of blood platelets Composition and bag for preservation of blood platelets

A - Human Necessities

61

K

A61K 35/14 (2006.01) A01N 1/02 (2006.01) A61J 1/05 (2006.01)

Patent

CA 2491893

Provided is a storage composition for preventing cold-induced platelet activation, comprising, plasma containing a plurality of platelets; a non-naturally occurring first agent for inhibiting actin filament severing; and a non-naturally occurring second agent for inhibiting actin polymerization, wherein the first and second agents are present in the composition in sufficient amounts so as to prevent cold-induced platelet activation. Also provided is a composition for preventing cold-induced platelet activation, the composition comprising: a first agent for inhibiting actin filament severing; and a second agent for inhibiting actin polymerization, wherein said composition does not contain platelets. Further provided is a platelet bag containing: a first agent for inhibiting actin filament severing; and a second agent for inhibiting actin polymerization.

Composé d'entreposage pour prévenir l'activation plaquettaire par le froid constitué de plasma contenant des plaquettes, d'un premier agent non naturel pour empêcher la séparation des filaments d'actine et d'un second agent non naturel pour empêcher la polymérisation de l'actine. Le premier et le second agent sont présents dans le composé en quantité suffisante pour empêcher l'activation plaquettaire par le froid. L'invention concerne aussi un composé pour empêcher l'activation plaquettaire par le froid constitué d'un premier agent pour empêcher la séparation des filaments d'actine et d'un second agent pour empêcher la polymérisation de l'actine, ce composé ne contenant pas de plaquettes. L'invention concerne en outre un sac pour les plaquettes contenant un premier agent pour empêcher la séparation des filaments d'actine et un second agent pour empêcher la polymérisation de l'actine.

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