A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/22 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2612864
A composition which comprises a solid or semi-solid matrix having at least one active ingredient uniformly dispersed therein, the matrix comprising at least one pharmaceutically acceptable matrix-forming agent and a 1,3-bis(lactamyl)- butane compound, in particular 1,3-bis(pyrrolidon-1-yl)-butane. The active ingredient is preferably dispersed in the matrix in a state of a solid solution. The matrix-forming agent is preferably a pharmaceutically acceptable polymer. The composition is useful for the manufacture of pharmaceutical dosage forms.
La présente invention concerne une composition qui comprend une matrice solide ou semi-solide ayant au moins une substance active dispersée uniformément dans celle-ci, la matrice comprenant au moins un agent de formation de matrice pharmaceutiquement acceptable et un composé de type 1,3-bis(lactamyl)butane, en particulier le 1,3-bis(pyrrolidon-1-yl)butane. La substance active est de préférence dispersée dans la matrice à l~état d~une solution solide. L'agent de formation de matrice est de préférence un polymère pharmaceutiquement acceptable. La composition est utile pour la fabrication de formes galéniques pharmaceutiques.
Breitenbach Joerg
Maegerlein Markus
Rosenberg Joerg
Abbott Gmbh & Co. Kg.
Borden Ladner Gervais Llp
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