Composition and dosage form comprising a solid or semi-solid...

A - Human Necessities – 61 – K

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A61K 47/22 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2612864

A composition which comprises a solid or semi-solid matrix having at least one active ingredient uniformly dispersed therein, the matrix comprising at least one pharmaceutically acceptable matrix-forming agent and a 1,3-bis(lactamyl)- butane compound, in particular 1,3-bis(pyrrolidon-1-yl)-butane. The active ingredient is preferably dispersed in the matrix in a state of a solid solution. The matrix-forming agent is preferably a pharmaceutically acceptable polymer. The composition is useful for the manufacture of pharmaceutical dosage forms.

La présente invention concerne une composition qui comprend une matrice solide ou semi-solide ayant au moins une substance active dispersée uniformément dans celle-ci, la matrice comprenant au moins un agent de formation de matrice pharmaceutiquement acceptable et un composé de type 1,3-bis(lactamyl)butane, en particulier le 1,3-bis(pyrrolidon-1-yl)butane. La substance active est de préférence dispersée dans la matrice à l~état d~une solution solide. L'agent de formation de matrice est de préférence un polymère pharmaceutiquement acceptable. La composition est utile pour la fabrication de formes galéniques pharmaceutiques.

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