Composition and imaging methods for pharmacokinetic and...

Details Composition and imaging methods for pharmacokinetic and... Composition and imaging methods for pharmacokinetic and...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61B 1/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2474138

A halogen-labeled gene therapy construct that includes halogen labeled nucleic acids, methods for preparing a halogenated gene therapy construct, and methods for in vivo imaging of the same. Also provided are methods for non-invasive drug detection in a subject using a labeled antibody that recognizes a heterologous antigen conjugated to, encoded by, or otherwise associated with the drug.

L'invention porte sur un gène hybride obtenu par thérapie génique marqué par un halogène et comprenant des acides nucléiques marqués par un halogène, sur des procédés de préparation du gène hybride halogéné ainsi que sur des procédés d'imagerie <i>in vivo</i> dudit gène. Font également l'objet de cette invention des procédés de détection de médicaments chez un patient utilisant un anticorps marqué reconnaissant un antigène hétérologue conjugué à, codé par ou sinon associé audit médicament.

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