Composition and method for acceleration of clot lysis

Details Composition and method for acceleration of clot lysis Composition and method for acceleration of clot lysis

A - Human Necessities

61

K

167/139

A61K 38/49 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07K 16/38 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341377

The present invention relates to a novel treatment for blood clots within a patient or myocardial infarction which comprises administering a hapten-binding molecule capable of preventing inhibition of plasmin by endogenous alpha-2- antiplasmin. The invention also relates to a treatment for blood clots within a patient or myocardial infarction compris- ing coadministrating the hapten-binding molecule of the invention together with a thrombolytic agent capable of either dissolving fibrin-platelet clots or inhibiting their forma- tion. The therapy of the invention is capable of increasing clot lysis while minimizing fibrinogen breakdown and prevent- ing the reocclusion of the affected coronary artery. The therapy of the present invention is capable of achieving this goal even in the absence of heparin and when the concentration of thrombolytic agent is lower than that required by other potential therapies.

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