C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 9/127 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07J 43/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2186542
The present invention provides a method for introducing nucleic acids into cells. The method involves exposing the cells to a compound having the formula Image in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a spacer having a chain length equivalent to 1-30 carbon- carbon single covalent bonds or is absent R4 is H or halogen or CH2O - R3; and R1, R2 and R3 are the same or different and are either hydrogen, methyl, ethyl, alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl groups or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl groups optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that at least one of R1, R2 or R3 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated, or to a compound having the formula: w.......x-y-NH--CH2-CH2O-R5 in which: w is a nucleic acid x is a non-amino acid or non-peptide nucleic acid binding group y is a spacer having a chain length equivalent to 1-30 carbon- carbon single covalent bonds or is absent R5 is alkyl, alkenyl, hydroxylated alkyl, hydroxylated alkenyl group or ether containing alkyl, alkenyl, hydroxylated alkyl or hydroxylated alkenyl group optionally being an acyl group having a carbon chain length equivalent to 3-24 carbon atoms saturated or unsaturated, with the proviso that R5 includes a group having a carbon chain of 3-24 carbon atoms saturated or unsaturated. The invention also relates to these compounds.
Cameron Fiona Helen
Carroll Simon Macewan
Lockett Trevor John
Moghaddam Minoo Jalili
Whittaker Robert George
Commonwealth Scientific And Industrial Research Organisation
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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