Composition and method for dermal and transdermal...

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) A61K 9/70 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 47/02 (2006.01) A61K 47/26 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2317698

A composition for transdermal administration of a cytokine is described. The composition includes a conjugate composed of a cytokine, such as an interferon, and at least one fatty acid moiety covalently attached to the cytokine. The conjugate has enhanced cutaneous delivery relative to the cytokine alone.

L'invention concerne une composition permettant l'administration transdermique d'une cytokine. La composition comprend un conjugué composé d'une cytokine, telle qu'un interféron, et au moins un fragment d'acide gras lié de manière covalente à la cytokine. Le conjugué présente un taux de pénétration cutanée amélioré en comparaison de la cytokine seule.

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