Composition and method for destruction of infectious prion...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/00 (2006.01) A61L 2/00 (2006.01) A61L 2/04 (2006.01) A61L 2/16 (2006.01)

Patent

CA 2442948

A method and composition for destruction of infectious prion proteins associated with transmissible spongiform encephalopathy (TSE) and/or other prion protein-mediated diseases, by thermal/enzymatic treatment of the infectious prion proteins with a prion-destructive protease. The method and composition are applicable to treatment of tissue containing or contaminated with infectious prion protein strains, or disinfection or sterilization of prion-contaminated articles, such as surgical instruments, kitchen utensils, laboratory tools, etc.

L'invention concerne une méthode et une composition de destruction des protéines prion infectieuses associées à l'encéphalopathie spongiforme transmissible (TSE) et/ou à d'autres maladies associées aux protéines prion, par traitement thermique/enzymatique des protéines prion infectieuses avec une protéase de destruction des prions. La méthode et la composition sont utilisées dans le traitement de tissus contenant ou contaminés par des souches de protéines prion infectieuses, ou la désinfection ou stérilisation d'articles contaminés par les prions, tels que les instruments chirurgicaux, les ustensiles de cuisine, les outils de laboratoire, etc.

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