Composition and method for detecting cancer with technetium...

Details Composition and method for detecting cancer with technetium... Composition and method for detecting cancer with technetium...

G - Physics

01

N

167/40

G01N 33/534 (2006.01) A61K 39/395 (2006.01)

Patent

CA 1186620

ABSTRACT OF THE DISCLOSURE This invention discloses F(ab')2 or Fab fragments of antibodies to: a) human chorionic gonadotropin (hCG), hCG alpha subunit, hCG beta subunit, or an hCG-like material; or b) other tumor specific or tumor associated molecules, to include carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), human melanoma associated antigens, human sarcoma associated antigens or other antigens, which are radiolaheled with technetium-99m (Tc-99m). When the F(ab')2 or Fab fragments of antibody to such tumor associated antigens are injected intra- venously into a patient, the radiolabeled composition accumulates at tumor sites. The accumulation of the cancer seeking radiopharmaceutical at tumor sites permits detection by external gamma scintigraphy. Thus, the composition is useful in the monitoring, localization and detection of cancer in the body.

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