C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2621070
A composition for detecting and diagnosing kidney cancer, diagnosing the metastasis of kidney cancer and/or estimating the prognosis of kidney cancer containing one or more polynucleotides selected from the group consisting of a polynucleotide, which shows a variation in the expression level in a kidney cancer cell originating in a patient with poor prognosis compared with a kidney cancer cell of a patient having favorable prognosis, its variant or a fragment thereof, or an antibody, which binds specifically to such a polypeptide showing a variation in the expression level as described above or its fragment, or a fragment thereof; a kit; a DNA chip; and utilization of the same.
L~invention a pour objet une composition permettant de détecter et de diagnostiquer un cancer du rein, de diagnostiquer les métastases d~un cancer du rein et/ou d~évaluer le pronostic vital d~un patient atteint de cancer du rein. La composition contient un ou plusieurs polynucléotides sélectionnés dans le groupe composé d~un polynucléotide présentant une variation du niveau d~expression dans une cellule cancéreuse du rein d~un patient au pronostic faible, par rapport à une cellule cancéreuse du rein d~un patient au pronostic favorable, sa variante ou un fragment de cette dernière, ou un anticorps fixant spécifiquement un tel polypeptide présentant une variation du niveau d~expression comme décrit ci-dessus ou son fragment ou un fragment de ce dernier ; un kit ; une puce à ADN et son utilisation.
Akiyama Hideo
Jung Giman
Kozono Satoko
Myomoto Akira
Nakamura Eijiro
Kyoto University
Smart & Biggar
Toray Industries Inc.
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