Composition and method for enhancing fibrinolysis using...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/38 (2006.01) C07K 16/46 (2006.01) C12N 5/18 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2266341

The present invention relates to a novel alpha-2-antiplasmin-binding molecules and treatment for pulmonary embolism, myocardial infarction, thrombosis or stroke in a patient which comprises administering an alpha-2-antiplasmin- binding molecule capable of preventing inibition of plasmin by endogenous alpha-2-antiplasmin. The invention also relates to a treatment for pulmonary embolism, myocardial infarction, thrombosis or stroke in a patient comprising coadministering an alpha-2-antiplasmin-binding molecule of the invention together with a thrombolytic agent.

Nouvelle molécule capable de liaison avec l'alpha-2-antiplasmine, et traitement pour l'embolie pulmonaire, l'infarctus du myocarde, la thrombose ou l'accident vasculaire cérébral chez un patient, qui consiste à administrer ce nouveau type de molécule capable d'empêcher l'inhibition de la plasmine par alpha-2-antiplasmine andogène. On décrit aussi un traitement pour l'embolie pulmonaire, l'infarctus du myocarde, la thrombose ou l'accident vasculaire cérébral chez un patient, qui consiste à administrer conjointement la molécule en question et un agent thrombolytique.

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