Composition and method for enhancing paracellular transport...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/11 (2006.01) A61K 47/26 (2006.01) C07H 21/04 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2304313

A composition and method for enhancing paracellular transport across cell layers in an animal comprising an antisense oligonucleotide hybridizable with a region of the messenger RNA coding for the protein occludin which, when hybridized to the occludin mRNA, interferes with its translation such that occludin function is disrupted and paracellular permeability is increased across an epithelial cell layer or an endothelial cell layer in an animal.

L'invention concerne une composition et un procédé d'amélioration du transport paracellulaire à travers les couches cellulaires chez un animal, comprenant un oligonucléotide antisens pouvant être hybridé avec une région de l'ARN messager codant pour la protéine occludine. Une fois hybridé avec l'occludine d'ARN messager, ledit oligonucléotide entrave sa traduction à tel point que la fonction occludine est interrompue et la perméabilité paracellulaire augmente à travers une couche cellulaire épithéliale ou une couche cellulaire endothéliale chez un animal.

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