Composition and method for improved bioavailability and...

A - Human Necessities – 61 – K

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A61K 31/515 (2006.01)

Patent

CA 2576832

The present invention relates to a composition and method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administering an oral dosage form of a sodium salt of 5,5-diphenyl barbituric acid to enhance the bioavailability of 5,5-diphenyl barbituric acid and brain delivery of same.

L'invention concerne une composition et un procédé permettant d'administrer un dérivé d'acide barbiturique au système nerveux central d'un mammifère nécessitant un traitement d'états neurologiques. Plus précisément, l'invention concerne un procédé permettant d'administrer par voie orale une forme posologique d'un sel de sodium d'acide 5,5-diphényl-barbiturique afin de renforcer la biodisponibilité de l'acide 5,5-diphényl-barbiturique ainsi que son administration au cerveau.

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